Mohammed began his career at CNN as a freelance reporter and producer while he was living in Saudi Arabia in late 2006. He then joined CNN's International Desk in late 2007 and until July 2010 worked as a full-time assignment editor. While in Atlanta, Mohammed also continued to work extensively on Middle East-based stories for CNN, both as a reporter and producer.

He was part of the team nominated for the 2010 News and Documentary Emmy Awards for CNN's coverage of the story of the failed attempt to down the Northwest Airlines flight from Schipol in the Netherlands to Detroit in the US on December 25, 2009. Prior to joining CNN, Jamjoom worked for Saudi Arabia’s English language Channel 2, where he worked as a co-anchor on its primetime news show.